The Pólya conjecture. For any N, write each number from 1 to N as a product of primes. Put all of the numbers that are written as a product of an odd number of primes on the left and put all the numbers that are written as a product of an even number of primes on the right. The conjecture states that the numbers on the right will never outnumber the numbers on the left. The smallest counterexample is N = 906,150,257.